Open position for a postdoctoral researcher in the Lari Lehtiö lab, Protein and Structural Biology research unit at the University of Oulu. Our team focuses on structure, function and selective inhibition of ADP-ribosyltransferases, also known as PARPs. Our goals are to discover and develop inhibitors targeting ADP-ribosyltransferases as well as ADP-ribosylhydrolases to be used as tools to study ADP-ribosylation events and also as potential anti-cancer and anti-viral drugs. We also study how the multidomain PARPs function by addressing several key questions in their oligomerization, protein-protein and protein-DNA interactions. Application deadline is November 30, 2022 (23:59 Finnish local time, EET).

The laboratory of Professor Pekka Katajisto at the Faculty of Biological and Environmental Sciences and Institute of Biotechnology, HiLIFE at the University of Helsinki, Finland, and at the Department of Cell and Molecular Biology, Karolinska Institutet, Sweden, is looking for a postdoctoral researcher with bioengineering background to study effects of the extracellular niche on stem cell function. Katajisto group is part of the Centre of Excellence in Stem Cell Metabolism, MetaStem, and studies stem cell extrinsic and intrinsic mechanisms of tissue renewal and aging.We seek postdoctoral researchers to an ERC-funded project probing how the geometry of the niche influences cell fate decisions using bioengineered scaffolds to modify tissue topology. The project involves development of novel research techniques and assays, and will be facilitated by state-of-the art maskless photolithography instrumentation dedicated to the project. Deadline for applications is December 16, 2022.